{"id":6718,"date":"2024-06-22T21:54:13","date_gmt":"2024-06-22T14:54:13","guid":{"rendered":"http:\/\/m.tapchinuocuc.net\/?p=6718"},"modified":"2024-06-22T21:54:48","modified_gmt":"2024-06-22T14:54:48","slug":"cac-nha-khoa-hoc-chung-minh-nhin-an-giup-chong-lai-cac-te-bao-un-g-th-u-phat-trien","status":"publish","type":"post","link":"http:\/\/m.tapchinuocuc.net\/?p=6718","title":{"rendered":"C\u00e1c nh\u00e0 khoa h\u1ecdc ch\u1ee9ng minh: NH\u1ecaN \u0102N gi\u00fap “ch\u1ed1ng” l\u1ea1i c\u00e1c t\u1ebf b\u00e0o un-g th-\u01b0 ph\u00e1t tri\u1ec3n."},"content":{"rendered":"
TPO – M\u1ed9t nh\u00f3m c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u t\u1eeb Vi\u1ec7n Sloan Kettering c\u1ee7a MSK v\u00e0 c\u00e1c c\u1ed9ng t\u00e1c vi\u00ean c\u1ee7a h\u1ecd l\u1ea7n \u0111\u1ea7u ti\u00ean \u0111\u00e3 ch\u1ee9ng minh r\u1eb1ng, nh\u1ecbn \u0103n c\u00f3 th\u1ec3 l\u1eadp tr\u00ecnh l\u1ea1i qu\u00e1 tr\u00ecnh trao \u0111\u1ed5i ch\u1ea5t c\u1ee7a c\u00e1c t\u1ebf b\u00e0o ti\u00eau di\u1ec7-t t\u1ef1 nhi\u00ean b\u00ean trong v\u00e0 xung quanh c\u00e1c kh\u1ed1i u, \u0111\u1ed3ng th\u1eddi c\u1ea3i thi\u1ec7n kh\u1ea3 n\u0103ng ch\u1ed1ng un-g th-\u01b0.<\/div>\n
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Minh h\u1ecda giai \u0111o\u1ea1n nh\u1ecbn \u0103n s\u1ebd l\u1eadp tr\u00ecnh l\u1ea1i c\u00e1c t\u1ebf b\u00e0o ti\u00eau di\u1ec7t t\u1ef1 nhi\u00ean c\u1ee7a h\u1ec7 th\u1ed1ng mi\u1ec5n d\u1ecbch \u0111\u1ec3 ch\u1ed1ng l\u1ea1i un-g th-\u01b0 t\u1ed1t h\u01a1n.<\/div>\n
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Nghi\u00ean c\u1ee9u n\u00e0y, d\u1eabn \u0111\u1ea7u b\u1edfi ti\u1ebfn s\u0129 Rebecca Delconte, v\u1eeba \u0111\u01b0\u1ee3c xu\u1ea5t b\u1ea3n tr\u00ean t\u1ea1p ch\u00ed Immunity. Nh\u1eefng ph\u00e1t hi\u1ec7n n\u00e0y c\u00f3 th\u1ec3 gi\u00fap gi\u1ea3i th\u00edch m\u1ed9t trong nh\u1eefng c\u01a1 ch\u1ebf m\u00e0 vi\u1ec7c nh\u1ecbn \u0103n c\u00f3 th\u1ec3 gi\u00fap c\u01a1 th\u1ec3 ch\u1ed1ng l\u1ea1i b\u1ec7nh ung th\u01b0 – c\u00f9ng v\u1edbi vi\u1ec7c gi\u1ea3m b\u00e9o n\u00f3i chung v\u00e0 c\u1ea3i thi\u1ec7n qu\u00e1 tr\u00ecnh trao \u0111\u1ed5i ch\u1ea5t.<\/span>K\u1ebft qu\u1ea3 n\u00e0y c\u0169ng cho th\u1ea5y nh\u1ecbn \u0103n c\u00f3 th\u1ec3 l\u00e0 m\u1ed9t chi\u1ebfn l\u01b0\u1ee3c nh\u1eb1m c\u1ea3i thi\u1ec7n ph\u1ea3n \u1ee9ng mi\u1ec5n d\u1ecbch \u0111\u1ec3 l\u00e0m cho li\u1ec7u ph\u00e1p mi\u1ec5n d\u1ecbch hi\u1ec7u qu\u1ea3 h\u01a1n.<\/p>\n

Nh\u00e0 nghi\u00ean c\u1ee9u mi\u1ec5n d\u1ecbch Joseph Sun, Ti\u1ebfn s\u0129, t\u00e1c gi\u1ea3 ch\u00ednh c\u1ee7a nghi\u00ean c\u1ee9u cho bi\u1ebft: \u201cC\u00e1c kh\u1ed1i u r\u1ea5t \u0111\u00f3i.Vi\u1ec7c nh\u1ecbn \u0103n s\u1ebd l\u1eadp tr\u00ecnh l\u1ea1i c\u00e1c t\u1ebf b\u00e0o ti\u00eau di\u1ec7t t\u1ef1 nhi\u00ean n\u00e0y \u0111\u1ec3 t\u1ed3n t\u1ea1i t\u1ed1t h\u01a1n trong m\u00f4i tr\u01b0\u1eddng \u1ee9c ch\u1ebf”.<\/p>\n

T\u1ebf b\u00e0o ti\u00eau di\u1ec7t t\u1ef1 nhi\u00ean l\u00e0 g\u00ec?<\/strong><\/p>\n

T\u1ebf b\u00e0o ti\u00eau di\u1ec7t t\u1ef1 nhi\u00ean, hay g\u1ecdi t\u1eaft l\u00e0 t\u1ebf b\u00e0o NK, l\u00e0 m\u1ed9t lo\u1ea1i t\u1ebf b\u00e0o b\u1ea1ch c\u1ea7u c\u00f3 th\u1ec3 ti\u00eau di-\u1ec7t c\u00e1c t\u1ebf b\u00e0o b\u1ea5t th\u01b0\u1eddng ho\u1eb7c b\u1ecb h\u01b0 h\u1ecfng, nh\u01b0 t\u1ebf b\u00e0o u-ng th-\u01b0 ho\u1eb7c t\u1ebf b\u00e0o b\u1ecb nhi\u1ec5m virus. Ch\u00fang c\u00f3 th\u1ec3 ti\u00eau di\u1ec7t m\u1ed1i \u0111e d\u1ecda m\u00e0 ch\u01b0a t\u1eebng g\u1eb7p ph\u1ea3i tr\u01b0\u1edbc \u0111\u00f3\u2014kh\u00f4ng gi\u1ed1ng nh\u01b0 t\u1ebf b\u00e0o T, v\u1ed1n \u0111\u00f2i h\u1ecfi ph\u1ea3i ti\u1ebfp x\u00fac tr\u01b0\u1edbc v\u1edbi m\u1ed9t k\u1ebb th\u00f9 c\u1ee5 th\u1ec3 \u0111\u1ec3 th\u1ef1c hi\u1ec7n ph\u1ea3n \u1ee9ng c\u00f3 ch\u1ee7 \u0111\u00edch. N\u00f3i chung, c\u00e0ng c\u00f3 nhi\u1ec1u t\u1ebf b\u00e0o NK trong kh\u1ed1i u th\u00ec c\u00e0ng t\u1ed1t.<\/p>\n

Trong nghi\u00ean c\u1ee9u, nh\u1eefng con chu\u1ed9t m\u1eafc b\u1ec7nh ung th\u01b0 b\u1ecb b\u1ecf \u0111\u00f3i trong 24 gi\u1edd, hai l\u1ea7n m\u1ed9t tu\u1ea7n v\u00e0 sau \u0111\u00f3 \u0111\u01b0\u1ee3c ph\u00e9p \u0103n tho\u1ea3i m\u00e1i gi\u1eefa c\u00e1c l\u1ea7n nh\u1ecbn \u0103n. Ti\u1ebfn s\u0129 Delconte cho bi\u1ebft, c\u0169ng gi\u1ed1ng nh\u01b0 \u1edf ng\u01b0\u1eddi, nh\u1eefng con chu\u1ed9t th\u1ea5y l\u01b0\u1ee3ng glucose gi\u1ea3m v\u00e0 l\u01b0\u1ee3ng axit b\u00e9o t\u1ef1 do t\u0103ng l\u00ean, l\u00e0 nh\u1eefng lipid \u0111\u01b0\u1ee3c gi\u1ea3i ph\u00f3ng b\u1edfi c\u00e1c t\u1ebf b\u00e0o m\u1ee1, c\u00f3 th\u1ec3 d\u00f9ng l\u00e0m ngu\u1ed3n n\u0103ng l\u01b0\u1ee3ng thay th\u1ebf khi kh\u00f4ng c\u00f3 c\u00e1c ch\u1ea5t dinh d\u01b0\u1ee1ng kh\u00e1c.<\/p>\n

Trong m\u1ed7i chu k\u1ef3 nh\u1ecbn \u0103n n\u00e0y, c\u00e1c t\u1ebf b\u00e0o NK \u0111\u00e3 h\u1ecdc c\u00e1ch s\u1eed d\u1ee5ng c\u00e1c axit b\u00e9o n\u00e0y l\u00e0m ngu\u1ed3n nhi\u00ean li\u1ec7u thay th\u1ebf cho glucose. \u0110i\u1ec1u n\u00e0y th\u1ef1c s\u1ef1 t\u1ed1i \u01b0u h\u00f3a ph\u1ea3n \u1ee9ng ch\u1ed1ng u-ng th-\u01b0 v\u00ec vi m\u00f4i tr\u01b0\u1eddng kh\u1ed1i u ch\u1ee9a n\u1ed3ng \u0111\u1ed9 lipid cao v\u00e0 ch\u00fang c\u00f3 th\u1ec3 x\u00e2m nh\u1eadp v\u00e0o kh\u1ed1i u v\u00e0 ti\u00eau di\u1ec7t ch\u00fang.<\/p>\n

Nh\u1ecbn \u0103n t\u00e1i l\u1eadp tr\u00ecnh t\u1ebf b\u00e0o NK<\/strong><\/p>\n

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C\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u quan s\u00e1t th\u1ea5y vi\u1ec7c nh\u1ecbn \u0103n c\u0169ng d\u1eabn \u0111\u1ebfn s\u1ef1 ph\u00e2n ph\u1ed1i l\u1ea1i c\u00e1c t\u1ebf b\u00e0o NK trong c\u01a1 th\u1ec3. Nhi\u1ec1u t\u1ebf b\u00e0o NK \u0111\u00e3 di chuy\u1ec3n v\u00e0o t\u1ee7y x\u01b0\u01a1ng, t\u1ea1i \u0111\u00e2y, nh\u1edd nh\u1ecbn \u0103n, ch\u00fang \u0111\u01b0\u1ee3c ti\u1ebfp x\u00fac v\u1edbi m\u1ee9c \u0111\u1ed9 cao c\u1ee7a m\u1ed9t lo\u1ea1i protein t\u00edn hi\u1ec7u quan tr\u1ecdng c\u00f3 t\u00ean l\u00e0 Interleukin-12. \u0110i\u1ec1u n\u00e0y th\u00fac \u0111\u1ea9y c\u00e1c t\u1ebf b\u00e0o NK s\u1ea3n sinh ra nhi\u1ec1u Interferon-gamma h\u01a1n\u2014m\u1ed9t lo\u1ea1i cytokine \u0111\u00f3ng vai tr\u00f2 quan tr\u1ecdng trong ph\u1ea3n \u1ee9ng ch\u1ed1ng kh\u1ed1i u.<\/p>\n

Trong khi \u0111\u00f3, c\u00e1c t\u1ebf b\u00e0o NK \u1edf l\u00e1 l\u00e1ch \u0111ang tr\u1ea3i qua qu\u00e1 tr\u00ecnh t\u00e1i l\u1eadp tr\u00ecnh ri\u00eang bi\u1ec7t, gi\u00fap ch\u00fang s\u1eed d\u1ee5ng lipid l\u00e0m ngu\u1ed3n nhi\u00ean li\u1ec7u t\u1ed1t h\u01a1n.<\/p>\n

Ti\u1ebfn s\u0129 Delconte cho bi\u1ebft: \u201cV\u1edbi c\u1ea3 hai c\u01a1 ch\u1ebf n\u00e0y k\u1ebft h\u1ee3p v\u1edbi nhau, ch\u00fang t\u00f4i th\u1ea5y r\u1eb1ng c\u00e1c t\u1ebf b\u00e0o NK \u0111\u00e3 \u0111\u01b0\u1ee3c chu\u1ea9n b\u1ecb s\u1eb5n \u0111\u1ec3 s\u1ea3n xu\u1ea5t nhi\u1ec1u cytokine h\u01a1n trong kh\u1ed1i u. V\u1edbi vi\u1ec7c t\u00e1i l\u1eadp tr\u00ecnh trao \u0111\u1ed5i ch\u1ea5t, ch\u00fang c\u00f3 nhi\u1ec1u kh\u1ea3 n\u0103ng s\u1ed1ng s\u00f3t h\u01a1n trong m\u00f4i tr\u01b0\u1eddng kh\u1ed1i u v\u00e0 chuy\u00ean bi\u1ec7t h\u00f3a \u0111\u1ec3 c\u1ea3i thi\u1ec7n c\u00e1c \u0111\u1eb7c t\u00ednh ch\u1ed1ng un-g t-h\u01b0”.<\/p>\n

M\u1eb7c d\u00f9 c\u00e1c m\u1eabu t\u1ee7y x\u01b0\u01a1ng c\u1ee7a con ng\u01b0\u1eddi kh\u00f4ng \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u nh\u01b0 m\u1ed9t ph\u1ea7n c\u1ee7a d\u1ef1 \u00e1n, nh\u01b0ng c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u l\u01b0u \u00fd r\u1eb1ng c\u00e1c m\u1eabu m\u00e1u t\u1eeb b\u1ec7nh nh\u00e2n ung th\u01b0 cho th\u1ea5y vi\u1ec7c nh\u1ecbn \u0103n l\u00e0m gi\u1ea3m c\u00e1c t\u1ebf b\u00e0o NK l\u01b0u th\u00f4ng t\u1ef1 do \u1edf ng\u01b0\u1eddi, gi\u1ed1ng nh\u01b0 nh\u1eefng g\u00ec h\u1ecd quan s\u00e1t th\u1ea5y \u1edf chu\u1ed9t.<\/p>\n

C\u1ea3i thi\u1ec7n ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb un-g th-\u01b0<\/strong><\/p>\n

C\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u cho bi\u1ebft c\u00f3 m\u1ed9t s\u1ed1 c\u01a1 h\u1ed9i ti\u1ec1m n\u0103ng \u0111\u1ec3 th\u00fac \u0111\u1ea9y nghi\u00ean c\u1ee9u tr\u00ean m\u00f4 h\u00ecnh chu\u1ed9t. \u0110\u1ea7u ti\u00ean, c\u00e1c th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng \u0111\u00e3 b\u1eaft \u0111\u1ea7u nghi\u00ean c\u1ee9u t\u00ednh an to\u00e0n v\u00e0 hi\u1ec7u qu\u1ea3 c\u1ee7a vi\u1ec7c nh\u1ecbn \u0103n k\u1ebft h\u1ee3p v\u1edbi c\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb ti\u00eau chu\u1ea9n hi\u1ec7n c\u00f3.<\/p>\n

M\u1ed9t con \u0111\u01b0\u1eddng kh\u00e1c l\u00e0 x\u00e1c \u0111\u1ecbnh c\u00e1c lo\u1ea1i thu\u1ed1c c\u00f3 th\u1ec3 nh\u1eafm v\u00e0o c\u00e1c c\u01a1 ch\u1ebf c\u01a1 b\u1ea3n m\u00e0 kh\u00f4ng y\u00eau c\u1ea7u b\u1ec7nh nh\u00e2n ph\u1ea3i nh\u1ecbn \u0103n. Th\u1ee9 ba, t\u1ebf b\u00e0o NK c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c \u0111\u01b0a v\u00e0o tr\u1ea1ng th\u00e1i nh\u1ecbn \u0103n b\u00ean ngo\u00e0i c\u01a1 th\u1ec3 v\u00e0 sau \u0111\u00f3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 c\u1ea3i thi\u1ec7n hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb.<\/p>\n

Neil Iyengar, MD, b\u00e1c s\u0129 ung th\u01b0 v\u00fa c\u1ee7a MSK v\u00e0 nh\u00e0 nghi\u00ean c\u1ee9u h\u00e0ng \u0111\u1ea7u v\u1ec1 ch\u1ebf \u0111\u1ed9 \u0103n u\u1ed1ng, trao \u0111\u1ed5i ch\u1ea5t v\u00e0 un-g th-\u01b0, cho bi\u1ebft: \u201cC\u00f3 nhi\u1ec1u ki\u1ec3u nh\u1ecbn \u0103n kh\u00e1c nhau v\u00e0 m\u1ed9t s\u1ed1 c\u00f3 th\u1ec3 h\u1eefu \u00edch trong khi nh\u1eefng ki\u1ec3u kh\u00e1c c\u00f3 th\u1ec3 c\u00f3 h\u1ea1i. B\u1ec7nh nh\u00e2n n\u00ean trao \u0111\u1ed5i v\u1edbi b\u00e1c s\u0129 v\u1ec1 nh\u1eefng g\u00ec an to\u00e0n v\u00e0 l\u00e0nh m\u1ea1nh cho t\u00ecnh tr\u1ea1ng c\u00e1 nh\u00e2n c\u1ee7a h\u1ecd”.<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

TPO – M\u1ed9t nh\u00f3m c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u t\u1eeb Vi\u1ec7n Sloan Kettering c\u1ee7a MSK v\u00e0 c\u00e1c c\u1ed9ng t\u00e1c vi\u00ean c\u1ee7a h\u1ecd l\u1ea7n \u0111\u1ea7u ti\u00ean \u0111\u00e3 ch\u1ee9ng minh r\u1eb1ng, nh\u1ecbn \u0103n c\u00f3 th\u1ec3 l\u1eadp tr\u00ecnh l\u1ea1i qu\u00e1 tr\u00ecnh trao \u0111\u1ed5i ch\u1ea5t c\u1ee7a c\u00e1c t\u1ebf b\u00e0o ti\u00eau di\u1ec7-t t\u1ef1 nhi\u00ean b\u00ean trong v\u00e0 xung quanh c\u00e1c kh\u1ed1i… Continue reading C\u00e1c nh\u00e0 khoa h\u1ecdc ch\u1ee9ng minh: NH\u1ecaN \u0102N gi\u00fap “ch\u1ed1ng” l\u1ea1i c\u00e1c t\u1ebf b\u00e0o un-g th-\u01b0 ph\u00e1t tri\u1ec3n.<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":6721,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4],"tags":[],"yoast_head":"\nC\u00e1c nh\u00e0 khoa h\u1ecdc ch\u1ee9ng minh: NH\u1ecaN \u0102N gi\u00fap "ch\u1ed1ng" l\u1ea1i c\u00e1c t\u1ebf b\u00e0o un-g th-\u01b0 ph\u00e1t tri\u1ec3n. - 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